Over 5 million Americans have taken the antidepressant Prozac. Many have become more confident, popular, mentally nimble, & emotionally resilient. The author looks at evidence from a variety of disciplines — cellular biology, animal ethology, medical ethics, literature, & at his own patients stories — to explore the implication of drugs that reshape temperament. A major contribution to late 20th century psychiatry & an extraordinarily eloquent, provocative, & moving tale about ourselves. A fascinating & beautifully written overview of the biology & psychology of mood-state. A richly philosophical meditation upon the basic nature of human nature.

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