Wilma Wasco and Rudolph Tanzi bring together in Molecular Mechanisms of Dementia the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. They also examine mechanisms by which ischemia and hypoxia result in dementia.

Wasco, Wilma (Massachusetts General Hospital); Tanzi, Rudolph E. (Massachusetts General Hospital)The contributors represent the specialties of neurology, pharmacology, genetics and aging research, Alzheimer's disease research, anatomy and neurobiology, chemistry, and pathology. Most are from universities, research institutes, and academic hospitals in the U.S., Italy, Canada, and the U.K. Institutions prominently represented include Univ of Kentucky, UC-Irvine, Univ of Western Ontario, Case Western Reserve Univ, Massachusetts General Hospital, and Univ of Arkansas for Medical Sciences.

Tags: molecular mechanisms dementia